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Women's health / Combination hormone therapy
Estradiol/Testosterone Cream
A combination hormone therapy pairing estrogen with low-dose testosterone, prescribed after a licensed provider reviews your health history.
- Private health intake
- Licensed provider review
- Treatment only when appropriate
Clinician-guided care
Illustrative care image. Actual medication and packaging may vary.
- Hormones
- Estradiol + testosterone
- Form
- Combination cream
- Added hormone
- Low-dose testosterone
- Access
- Provider review
Treatment overview
What It Is & How It Works
This cream combines estradiol with a low dose of testosterone. Estradiol addresses estrogen-related symptoms, while low-dose testosterone is sometimes included to help support energy, mood, and libido when clinically appropriate.
How treatment works
A provider-guided treatment plan
Provider review
A licensed provider reviews your information and determines whether a combination of estradiol and low-dose testosterone may be appropriate.
Treatment guidance
If prescribed, your provider explains how to use the cream and how the treatment will be monitored.
Eligibility
Is This Right For You?
This combination may be considered when both hormones align with a patient’s symptoms and treatment goals. Your provider will review your health history to determine whether treatment is appropriate.
Important safety information
Safety & Side Effects
Mild application site irritation is possible.
Your provider will review the full safety profile with you, including standard considerations that apply to both estrogen and testosterone therapy.
Frequently asked questions
Before you begin
Why might low-dose testosterone be included?
Low-dose testosterone is sometimes used in women to help support energy, mood, and libido alongside estrogen therapy. Your provider can discuss whether this fits your goals.
Will this cream affect my voice or cause other masculinizing effects?
The testosterone dose in this formula is low and monitored by your provider specifically to minimize this risk. Your provider will discuss this with you directly.
How is this different from Estradiol Cream alone?
This version adds low-dose testosterone to estradiol therapy. Your provider can help determine which option better fits your symptoms and goals.